Myocardial Protein Metabolism Following Coronary Occlusion
نویسندگان
چکیده
منابع مشابه
Myocardial blood flow following experimental coronary occlusion. Effects of diltiazem.
To determine the effects of diltiazem, a new calcium antagonist, on myocardial ischemia, two experiments were performed. The results showed 1) the intravenous holus injection of large doses of diltiazem reduced ST segment elevation in open-chest dogs with acute coronary occlusion. The regional myocardial blood flow in the control area, as well as moderately and mildly ischemic areas increased s...
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Electrocardiographic, enzymatic, and morphologic signs of myocardial ischemic injury following coronary occlusion have previously been shown to be ameliorated by reducing myocardial oxygen requirements, and/or by increasing the availability of oxygen as well as of substrates for anaerobic ATP production. Since hyaluronidase increases diffusion through the extracellular space and may facilitate ...
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Changes in high-energy phosphate metabolism may be important in the regulation of myocardial contractile function during ischemia. This study sought to determine the dynamic relation between myocardial contractile function and high-energy phosphate metabolism during and following brief (24-second) coronary occlusion, when large and rapid changes in both parameters occur. Eight anesthetized, ope...
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BACKGROUND Rapid reperfusion of an occluded coronary artery salvages regional mechanical function, but this benefit may not be realized for hours or days because of postischemic stunning. Recovery from stunning is incompletely understood but may involve adaptive changes in heart glucose metabolism. METHODS AND RESULTS To examine whether reversible coronary occlusion produces sustained changes...
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The effect of propranolol on the severity of myocardial necrosis following 40 minutes of temporary coronary artery occlusion was assessed in dogs. The circumflex coronary artery was occluded 1—2 cm from the aorta in open-chest dogs anesthetized with sodium pentobarbital. One group of dogs was untreated and a second group received propranolol (5.0 mg/kg, iv) 10 minutes prior to the occlusion. Af...
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ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 1967
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.31.581